Which ethics committee should I apply to?
There are currently the following different application routes for UCL staff and students whose projects require research ethics approval:
- NHS Research Ethics Review – any research that involves NHS patients and carers, invasive research involving prisoners or adults lacking capacity, a Clinical Trial of an Investigational Medicinal Product or human tissue. Please refer to → HRA checklist, → the HRA’s decision tool.
- Social Care Research Ethics Committee (SCREC) – ethical approval is required through SCREC for social care research projects funded by the → Department of Health.
- Ministry of Defence Research Ethics Committee (MoDREC) – ethical approval is required through → MoDREC for research involving human participants either undertaken, funded or sponsored by MOD in order to meet nationally and internationally accepted ethical standards.
- University Ethics Review – If your research does not fall into the above categories and it involves human participants, their tissue and/or data should apply to one of the following two ethics committees at UCL:
UCL Research Ethics Committee – for all UCL staff and students
UCL Institute of Education Research (IoE) Ethics Committee – for all IoE staff, students and visitors. The Institute maintains its own REC and policy separate from the UCL REC. For the Institute, all research projects which collect or use data from human participants including secondary data analysis and systematic reviews require ethical approval before the project starts. This includes preliminary and pilot studies. → Further details.
If you are unsure about the type of ethical review that is required please email: email@example.com for advice.
It should be noted that some studies that fall outside of the review requirements of the UK Health Departments' Research Ethics Service will still also require approval/management permission from the host care organisations, often called R&D approval. For all UCLH, RFH and Institute of Neurology staff undertaking medical research the → Joint Research Office provides all the information for i) R and D approval at UCLH; ii) Research contracts with UCLH both commercial and non-commercial; iii) for research governance and keeping your study legal; iv) training and education in research governance; v) collaborations with statisticians.
Please note that Multi Research Ethics Committee (MREC) approval may be necessary if it is a multi-centre study (i.e. involving more than one research site).
The UCL Research Ethics Committee
Ethical approval is required through the UCL REC if a specific research project is:
- a non-NHS study involving human participants and the collection and/or study of data derived from living human participants undertaken by UCL staff or students on the UCL premises and/or by UCL staff or students elsewhere;
- a study involving NHS staff recruited as research participants by virtue of their professional role;
- a study on NHS premises, involving healthy volunteers not recruited as NHS patients and not subject to any legal requirements;
- a clinical trial conducted overseas;
- a 'mechanistic' study in which a drug is used to investigate a physiological process in healthy volunteers;
- a study involving a CE-marked medical device that has not been modified or is not being used for a new purpose.
- involves more than minimal risk
to ensure that the research conforms with general ethical principles and standards unless:
- the only involvement of human participants in particular research activities will be one or more of the categories listed in our → exemptions in which case the research will be EXEMPT from ethics approval unless approval is specifically required by an external funding body or other external body in order to obtain research permission;
- UCL staff are involved as co-researchers in a project led by a Principal Researcher from another UK institution and ethics approval has been granted by that institution. Please note that for studies conducted overseas, ethical approval from both a UK and a local institution is required.
If research is exempt from formal approval under the following criteria, it is still expected that UCL researchers will abide by the appropriate ethical guidelines of their discipline.
Department Heads have final judgment as to whether a particular activity should be exempt from the requirement for approval by the UCL Ethics Committee. But note that the exemptions do not apply to research involving vulnerable participants as defined in our guidelines.
Exemption from approval by the UCL Ethics Committee DOES NOT IMPLY that the research is also exempt from registration with the UCL Data Protection Officer nor from UCL Risk Assessment procedures.
If your study is not exempt from ethical approval you will need to submit an application to the UCL Research Ethics Committee. Please follow the steps on our → Procedures for Applicants page.
When the researcher is based at UCL but conducting research outside Britain, or in the case of collaborative research with international institutions, the researcher should, where possible, refer to international guidelines for the country where research is being carried out in addition to applying for approval from the UCL Research Ethics Committee. In cases where ethical or legal permissions are required from local organisations or gatekeepers, it is the researchers responsibility to ensure that these have been obtained prior to commencing the study.
The → ICoHPS listing compiled by the Office for Human Research Protections, US Department of Health and Human Services provides details of Research Ethics Committees in over 100 countries. It is also recommended that researchers regularly check the → British Foreign Commonwealth Office website for further details and travel advice for the country they are planning to travel to.